Matthew Long

Cancer cells acquire cysteine directly from a reduced tumor microenvironment

The paper shows cancer cells in the lung take up cysteine and cystine efficiently, and the reduced tumor microenvironment supports their growth and resistance to oxidative stress.

A simple, anesthesia-free infusion technique for in vivo metabolic tracing

The paper introduces an anesthesia-free infusion technique for in vivo metabolic tracing in mice, achieving steady-state labeling comparable to jugular infusion without excessive cystine accumulation.

PHGDH is a targetable driver of PDAC progression

This study identifies PHGDH as a driver of PDAC progression by maintaining glutamine metabolism and mTOR signaling, revealing a therapeutic vulnerability to glutamine antagonism in PHGDH-deficient tumors.