Frank W. Pfrieger

This study uses iPSC-derived neurons from NPC1 patients to show that BET inhibition with JQ1 improves neuronal viability and reduces cholesterol accumulation.

The paper identifies perivascular cells as phagocytes that clear CNS debris and shows Axl inhibition reduces pathology and improves recovery after spinal cord injury.

This study investigates the effects of bromodomain protein inhibition in a mouse model of Niemann-Pick type C disease, finding sex-dependent therapeutic benefits in male mice.

This study investigates bromodomain proteins as a therapeutic target for Niemann-Pick type C disease, showing that JQ1 improves NPC1 levels and reduces cholesterol accumulation in patient-derived fibroblasts.

The paper shows that oxytocin-induced astrocyte process retraction in the amygdala modulates freezing behavior during stress by enhancing neuronal sensitivity to potassium.

The paper identifies VAMP5 as a SNARE component in extracellular vesicles released by retinal Muller glia and shows differences in their secretomes compared to neurons.

This study investigates how cyclodextrin reverses cholesterol accumulation in NPC1-deficient neurons by involving glial cells in lipid removal.