Norikazu Ichihashi

The paper demonstrates cooperative genomic RNA replication in artificial multicellular-like droplet colonies through molecular communication.

The paper constructs non-standard genetic codes in vitro and shows that mutational robustness of reporter proteins remains similar despite changes in genetic code, supporting the error minimization theory.

This study shows that random RNA pools can exhibit weak heritability through sequence and structural persistence, suggesting an early mechanism for information propagation before enzymatic life.

This paper develops a theoretical framework to predict sustainable regeneration of translation factors EF-Tu and IF3 and demonstrates experimental success for up to 20 rounds of co-regeneration.

The paper develops a two-step in vitro evolution method to improve translational proteins and identifies mutations that enhance translation activity.

The paper improves the tRNA array method to enhance translational activity for multiple reporter proteins under various conditions.

This study shows that co-evolution between host and parasitic RNA replicators can lead to diversity loss and frequent extinctions under specific dilution conditions.

This study develops a framework to model coevolution of molecular replicators and parasites with transient compartmentalization, showing compositional memory influences early molecular system dynamics.

This study develops a tRNA array method to simultaneously express all 21 tRNAs in vitro, supporting translation and genetic code engineering.

The paper develops a reconstituted system that sustainably regenerates all 20 aminoacyl-tRNA synthetases for up to 20 cycles.