Janet Zoldan

This study shows that vascular network formation by hiPSC-derived endothelial progenitors in 3D hydrogels depends on matrix stiffness, contractility, and cell-induced remodeling, not just mechanotransduction.

This study shows that dynamically adjusting hydrogel stiffness during vasculogenesis improves vascular network formation, while late stiffening disrupts it, with effects mediated by FAK and Rho kinase.

This study shows that tuning hydrogel degradation using non-natural peptoid substitutions affects HUVEC morphology and vessel formation by altering MMP secretion.

The paper uses cell barcoding to show that hiPSC lineages have different differentiation outcomes into cardiomyocytes, highlighting lineage-dependent variability in cardiac differentiation.

This study shows that dynamic electrical stimulation improves hiPSC-CM differentiation, functionality, and transcriptomic pathway enrichment compared to static or no stimulation.

This study optimizes cardiac organoid culture conditions by testing seeding density and culture duration, finding that 20,000 cells seeded for seven days yield the most mature, viable, and cardiotoxicity-sensitive organoids.

This study shows that donor age impairs the vasculogenic potential of hiPSC-derived endothelial progenitors, with older donor cells forming less functional vascular structures and showing epigenetic and transcriptomic differences.

This study examines how 3D microenvironment mechanics influence hiPSC-derived endothelial progenitor cell self-assembly and network formation.

This paper compares two hiPSC differentiation protocols for endothelial progenitors, finding significant differences in cell maturity, phenotype, and vasculogenic potential.