Bryce Larsen

This study shows that vascular network formation by hiPSC-derived endothelial progenitors in 3D hydrogels depends on matrix stiffness, contractility, and cell-induced remodeling, not just mechanotransduction.

This study shows that dynamically adjusting hydrogel stiffness during vasculogenesis improves vascular network formation, while late stiffening disrupts it, with effects mediated by FAK and Rho kinase.

This study shows that donor age impairs the vasculogenic potential of hiPSC-derived endothelial progenitors, with older donor cells forming less functional vascular structures and showing epigenetic and transcriptomic differences.

This paper compares two hiPSC differentiation protocols for endothelial progenitors, finding significant differences in cell maturity, phenotype, and vasculogenic potential.