Anthony C.F. Perry

Metastatic founder cell candidates resemble preimplantation embryonic blastomeres

The paper identifies metastatic founder cell candidates in bone marrow that resemble preimplantation embryonic blastomeres, linking cancer metastasis to early embryonic development mechanisms.

Novel imprints in mouse blastocysts are predominantly DNA methylation independent

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.

Mouse fertilization triggers a conserved transcription program in one-cell embryos

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.

Switchable genome editing via genetic code expansion

This paper develops a BOC-dependent CRISPR-Cas9 system for controlled genome editing in mammals, enabling heritable edits only after BOC exposure.