Martin Hoffmann

Ex vivo drug testing in metastatic biopsies reveals patient-specific vulnerabilities to cancer targeting and immune activating drugs

This study introduces PEDRA, an ex vivo drug response assay that identifies patient-specific treatment options in metastatic biopsies, outperforming prior therapies and informing immune responses.

Plastimos: a live cell imaging-based framework to study dynamics of EMT-mediated cellular plasticity in breast cancer

Plastimos quantifies EMT-mediated cellular plasticity in breast cancer cells using live cell imaging and deep learning, showing differential responses to EGF and TGF-β1.

Multiscale Detrended Cross-Correlation Coefficient: Estimating Coupling in Nonstationary Neurophysiological Signals

This paper introduces MDC3, a novel estimator for coupling in neurophysiological signals, showing it outperforms Pearson correlation in accuracy for both simulated and real data.

Mouse fertilization triggers a conserved transcription program in one-cell embryos

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.

Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification

The paper develops a single-cell qPCR assay to accurately quantify ERBB2 expression in disseminated cancer cells, showing it can detect expression even in HER2-negative cells.