Peter‐Martin Bruch

Spatial organization of fibroblast subpopulations and niches across acute repair and chronic fibrotic remodeling of the human myocardium

This study identifies spatially distinct fibroblast subpopulations and niches in human myocardial fibrosis across different disease states and their associations with fibrotic remodeling and cardiac dysfunction.

A dual-photoreactive adapter enables one-step DNA barcoding of antibody panels for multiplexed imaging

This paper introduces a dual-photoreactive adapter to enable rapid, one-step DNA barcoding of antibody panels for multiplexed imaging.

Spatialproteomics - an interoperable toolbox for analyzing highly multiplexed fluorescence image data

The paper introduces spatialproteomics, a Python toolbox for analyzing highly multiplexed fluorescence images, demonstrating its use on lymph node and lymphoma data.

Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis

This study uses blood vessel organoids to model systemic sclerosis vasculopathy and fibrosis, showing that SSc serum induces epigenetic and molecular changes linked to endothelial dysfunction and potential therapeutic targets.

Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation

This paper introduces scNOVA, a method to analyze somatic structural variants in single-cell multiomics data, revealing their functional impacts on gene regulation and cancer pathways.

Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF

diffTF quantifies differential transcription factor activity and classifies TFs as activators or repressors using multi-omics data, identifying known and novel TFs in two case studies.