Author

Karen Grimes

European Molecular Biology LaboratoryORCID 0000-0002-4805-2366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jan O. KorbeliD· 3 shared Ashley D. SandersiD· 2 shared Daniel NowakiD· 2 shared Hyobin JeongiD· 2 shared Johann-Christoph JanniD· 2 shared Patrick HasenfeldiD· 2 shared Tobias RauschiD· 2 shared Alexandra Eliassaf· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Jan O. KorbelORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 17, 2025

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov…·Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

1 citation

humanexperimental assay

𝕏 PostBluesky

GenomicsNature GeneticsPeer-reviewedMay 28, 2024

Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells

Karen Grimes, Hyobin Jeong, Amanda Amoah…·Jan O. Korbel

This study identifies cell type-specific molecular consequences of mosaic structural variants in hematopoietic stem and progenitor cells across aging.

22 citationstop 3%

humanscRNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintNov 11, 2021

Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation

Hyobin Jeong, Karen Grimes, Peter‐Martin Bruch…·Jan O. Korbel

This paper introduces scNOVA, a method to analyze somatic structural variants in single-cell multiomics data, revealing their functional impacts on gene regulation and cancer pathways.

4 citations

humanscRNA-seq

𝕏 PostBluesky