Zhe Li

RUNX1-deficiency drives immune-active ER+ mammary tumorigenesis through activation of interferon signaling

This study shows that RUNX1 loss in ER+ breast cancer promotes immune-active tumor formation through interferon signaling activation.

LSD1 ablation promotes mammary tumor metastasis by attenuating NK cell-mediated anti-tumor immunity

This study shows that LSD1 ablation in mammary tumor cells reduces NK cell-mediated anti-tumor immunity, leading to increased lung metastasis.

Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways

This study shows that estrogen receptor signaling in fallopian tube stromal cells maintains epithelial homeostasis by promoting proliferation and ciliated differentiation, but excessive estrogen shifts this niche toward inflammation and stemness, contributing to cancer initiation.

Neuronal activity promotes repair by microglial reprogramming following demyelination

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.