Jeffrey N. Weiser

This study identifies IL-17RA and IL-1R signaling pathways that prevent persistent pneumococcal colonization by regulating neutrophil replenishment and activation in mice.

This study identifies host and bacterial factors influencing acquisition of Streptococcus pneumoniae in mice, showing that prior viral infection and capsule expression enhance acquisition, while prior colonization blocks it.

This study shows that the capsule of Streptococcus pneumoniae inhibits natural transformation by hindering Com pilus assembly, with effects varying by serotype and capsule amount.

The paper uses genome-wide association studies to show human and pneumococcal genetic variation influences susceptibility and severity of pneumococcal meningitis.

PopPUNK provides fast, scalable clustering of bacterial genomes using k-mer analysis, enabling real-time outbreak detection and stable cluster naming across species and datasets.

pyseer is a tool for microbial pangenome-wide association studies that integrates various methods, offers flexible input data handling, and provides new ways to interpret results.