Diederik van de Beek

Temporal Dynamics of Complement Activation and Outcome in Patients with Acute Ischemic Stroke

The paper examines complement activation dynamics in acute ischemic stroke patients and controls, finding pathway-specific markers associated with outcomes.

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

The paper uses genome-wide association studies to show human and pneumococcal genetic variation influences susceptibility and severity of pneumococcal meningitis.

Temporal population structure of invasive Group B Streptococcus during a period of rising disease incidence shows expansion of a CC17 clone

The paper uses whole genome sequencing to analyze invasive GBS isolates in the Netherlands and identifies the expansion of a CC17 sub-lineage, CC17-1A, as correlated with increased disease incidence.

Large scale genomic analysis shows no evidence for repeated pathogen adaptation during the invasive phase of bacterial meningitis in humans

This study analyzes genomic variation in meningitis pathogens to determine if adaptation occurs during the invasive phase, finding no evidence of such adaptation for four species.