Author

Mark T. Handley

State University of New YorkORCID 0000-0001-7200-747XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kaalak ReddyiD· 3 shared J. Andrew BerglundiD· 2 shared Alex M. ValmiD· 1 shared Alex von KriegsheimiD· 1 shared Alison M. MeynertiD· 1 shared Andrew J. FinchiD· 1 shared Andrew P. JacksoniD· 1 shared Aradhana Pandey· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Kaalak ReddyORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 17, 2026

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature

Jacob H Schroader, Naa N. Adade, Emmanuel E. Adade…·Kaalak Reddy

This study shows that inosine misincorporation into mRNA activates the integrated stress response and an innate immune gene expression signature, linking ITPase deficiency to cellular stress.

1 citation

humanbulk RNA-seq

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Molecular BiologyNAR Molecular MedicinePeer-reviewedJan 1, 2026

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Subodh Kumar Mishra, Sawyer M Hicks, Jesus Frias…·J. Andrew Berglund

Quercetin reduces toxic RNA levels and rescues MBNL-dependent mis-splicing in DM1 and DM2 models.

11 citationstop 1%

humanmouse

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GeneticsPLoS GeneticsPeer-reviewedMar 11, 2019

ITPase Deficiency Causes Martsolf Syndrome With a Lethal Infantile Dilated Cardiomyopathy

Mark T. Handley, Kaalak Reddy, Jimi C. Wills…·David R FitzPatrick

This paper identifies ITPA mutations causing a lethal infantile dilated cardiomyopathy with Martsolf syndrome features and describes the molecular consequences of ITPase deficiency.

32 citations

humanDNA methylation

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