Boaz Goldberg

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

Differential effect of supercoiling on bacterial transcription in topological domains

This paper develops a computational model to quantify how DNA supercoiling and topoisomerases regulate bacterial transcription, showing distinct roles for topoisomerase I and gyrase in gene expression.