Cancer BiologybioRxivPreprint
Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma
Allison Marie May, Suguru Kadomoto, Claire Williams…·Evan T. Keller
The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.