Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma
Allison Marie May, Suguru Kadomoto, Claire Williams, Alex C. Soupir, Stephanie The, Jake J. McGue, Tyler Robinson, Greg Shelley, Mitchell T. Hayes, Brooke L. Fridley, Jodi A. Balasi, Paola M. Ramos Echevarria, Jasreman Dhillon, Srinivas Nallandhighal, Satwik Acharyya, , Evan T. Keller
The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.
bioRxiv · Jun 12, 2025 · PreprintCancer Biology