Author

Greg Shelley

University of MichiganORCID 0009-0004-9724-9140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Evan T. KelleriD· 3 shared Allison Marie MayiD· 2 shared Sethuramasundaram PitchiayaiD· 2 shared Tyler RobinsoniD· 2 shared Aaron M. UdageriD· 1 shared Alex C. SoupiriD· 1 shared Arul M. ChinnaiyaniD· 1 shared Brandon J. ManleyiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Evan T. KellerORCID

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3 papers

Recent·Most cited

A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate.

Greg Shelley, Allison Marie May, Tyler Robinson, Jinlu Dai, Sethuramasundaram Pitchiaya, Evan T. Keller

This study maps the spatiotemporal changes in mouse prostate cellular composition and gene expression after orchiectomy-induced androgen deprivation, identifying new fibroblast subtypes and altered intercellular communication.

Neoplasia · Sep 23, 2025Peer-reviewedCancer Biology

Cellular cartography reveals mouse prostate organization and determinants of castration resistance

Hanbyul Cho, Yuping Zhang, Jean Ching-Yi Tien, Rahul Mannan, Jie Luo, Sathiya Pandi Narayanan, Somnath Mahapatra, Jingzhou Hu, Greg Shelley, Gabriel Cruz, Miriam Shahine, Lisha Wang, Fengyun Su, Rui Wang, Xuhong Cao, , Arul M. Chinnaiyan

This study maps the mouse prostate's cellular organization and identifies key determinants of castration resistance using single-cell and spatial transcriptomics.

Proceedings of the National Academy of Sciences · Aug 25, 2025Peer-reviewedCancer Biology

Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma

Allison Marie May, Suguru Kadomoto, Claire Williams, Alex C. Soupir, Stephanie The, Jake J. McGue, Tyler Robinson, Greg Shelley, Mitchell T. Hayes, Brooke L. Fridley, Jodi A. Balasi, Paola M. Ramos Echevarria, Jasreman Dhillon, Srinivas Nallandhighal, Satwik Acharyya, , Evan T. Keller

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

bioRxiv · Jun 12, 2025 · PreprintCancer Biology