Chelsea Szu‐Tu

The paper develops sc-lentiMPRA to analyze enhancer activity and specificity in single cells during differentiation, finding motif affinity influences TF response patterns.

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

The paper identifies design principles of cell-state specific enhancers by analyzing synthetic DNA sequences in hematopoietic differentiation.

The paper identifies and profiles leukemic and pre-leukemic stem cells using single-cell transcriptomics combined with lineage tracing via somatic variants.

The paper describes a fast, low-cost method for preparing whole-genome sequencing libraries from yeast cells, enabling high-throughput analysis of genetic edits and polymorphisms.

The paper systematically maps the functional role of phosphorylation by analyzing phospho-deficient mutants in yeast and linking yeast phenotypes to human functional relevance.