Author

Alessandro Luciani

University of ZurichORCID 0000-0001-7219-3719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Olivier DevuystiD· 2 shared Svenja Aline KelleriD· 2 shared Zhiyong CheniD· 2 shared Han Lai· 1 shared Isabelle A. M. WormsiD· 1 shared Monica Goldade· 1 shared Patrick KrohniD· 1 shared Stephan C. F. NeuhaussiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Olivier DevuystORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyDisease Models & MechanismsPeer-reviewedApr 7, 2026

A Novel Zebrafish Luminescent Biosensor for Kidney Tubulopathy, Metal Toxicity, and Drug Screening

Han Lai, Monica Goldade, Svenja Aline Keller…·Zhiyong Chen

The paper introduces a zebrafish biosensor for detecting kidney tubule dysfunction and uses it to study metal toxicity and drug screening.

DOI 10.1242/dmm.052673

zebrafishimaging

𝕏 PostBluesky

PathologybioRxivPreprintFeb 3, 2026

SGLT2 Inhibitors Rescue Lysosomal mTORC1 Hyperactivity and Proximal Tubulopathy in Preclinical Models of Cystinosis

Svenja Aline Keller, Patrick Krohn, Zhiyong Chen…·Olivier Devuyst

This study shows SGLT2 inhibitors reduce mTORC1 hyperactivity and proximal tubulopathy in cystinosis models by altering lysosomal metabolism, independent of cystine clearance.

DOI 10.64898/2026.01.29.702541

𝕏 PostBluesky