Olivier Devuyst

This paper evaluates base editing strategies for treating ADTKD-UMOD by correcting pathogenic UMOD variants and inactivating mutant alleles, showing efficient correction and expression modulation in cell models.

This study investigates how MMUT deficiency affects mitochondrial energy production in different cell types and variants, finding cell-type and variant-dependent effects.

The paper introduces a zebrafish biosensor for detecting kidney tubule dysfunction and uses it to study metal toxicity and drug screening.

This study shows SGLT2 inhibitors reduce mTORC1 hyperactivity and proximal tubulopathy in cystinosis models by altering lysosomal metabolism, independent of cystine clearance.

This paper establishes a Drosophila model for Dent disease, showing that ClC-c depletion causes Cubilin ER retention and secretory pathway defects, revealing a new pathogenic mechanism.

This study identifies AQP1 as a BAT silencing factor and shows that its knockout activates NST under cold conditions, protecting against diet-induced obesity and metabolic dysfunction.

This study investigates allelic and gene dosage effects of UMOD mutations in ADTKD, showing toxic aggregates and ER stress contribute to kidney disease progression.

The paper identifies an intermediate-effect variant in UMOD associated with chronic kidney disease risk and shows it has reduced disease severity compared to canonical ADTKD mutations.

This study profiles mRNA and protein levels in aging kidneys, finding that protein changes reveal more extensive and functionally significant aging-related alterations than mRNA.