Anne C. Hart

The paper introduces C. elegans models of Alternating Hemiplegia of Childhood (AHC) by introducing AHC-causing ATP1A3 mutations into the orthologous gene, revealing dominant neuromuscular junction defects.

WormCat is a web-based tool for annotating and visualizing gene set enrichment in C. elegans datasets, identifying both known and novel biological categories.

This study uses C. elegans knock-in models to show that autophagy dysfunction contributes to neuronal defects in FUS-related ALS, independent of SQSTM1/p62 function.