Author

Frankie D. Heyward

Broad InstituteORCID 0000-0003-1722-5129Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Evan D. RoseniD· 2 shared Anton GulkoiD· 1 shared Aykut Göktürk ÜneriD· 1 shared Christopher L. JacobsiD· 1 shared Harini SrinivasaniD· 1 shared Hui PaniD· 1 shared Jonathan M. DreyfussiD· 1 shared Linus Tsai· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

Evan D. RosenORCID

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3 papers

Recent·Most cited

PhysiologyiSciencePeer-reviewedMar 5, 2026

Evidence of persistent hyperphagia following a dietary weight-loss intervention in mice

Frankie D. Heyward, Evan D. Rosen

This study shows that mice exhibit persistent hyperphagia after a weight-loss intervention, with weight regain linked to initial weight gain on a high-fat diet.

2 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 6, 2025

Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity

Frankie D. Heyward, Hui Pan, Jonathan M. Dreyfuss

DOI 10.1101/2025.10.06.680592

mousescRNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedMay 31, 2024

Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin's hunger-suppressing effects

Frankie D. Heyward, Nan Liu, Christopher L. Jacobs…·Evan D. Rosen

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

13 citations

mousescRNA-seq

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