Author

Yixing Yuchi

Joslin Diabetes CenterORCID 0000-0002-9439-0913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Mary‐Elizabeth PattiiD· 2 shared Vissarion EfthymiouiD· 2 shared Allison B. GoldfineiD· 1 shared Anish A. Konkar· 1 shared Ashley H. VernoniD· 1 shared Barbara B. KahniD· 1 shared Brandon W. HiggsiD· 1 shared Chisayo KozukaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersSystems Biology

Mary‐Elizabeth PattiORCID

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2 papers

Recent·Most cited

Systems BiologyDiabetesPeer-reviewedJan 31, 2022

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

Chisayo Kozuka, Vissarion Efthymiou, Vicência Sales…·Mary‐Elizabeth Patti

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

11 citations

mousehuman

𝕏 PostBluesky

Systems BiologyNature CommunicationsPeer-reviewedNov 29, 2021

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

Jonathan M. Dreyfuss, Yixing Yuchi, Xuehong Dong…·Mary‐Elizabeth Patti

The paper identifies mediators of improved glycemia after gastric bypass surgery using a high-throughput mediation analysis method applied to plasma proteome and metabolome data.

34 citationstop 3%

humanproteomics

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