Johnathon R. Emlaw

Asynchronous subunit transitions precede acetylcholine receptor activation

The paper uses cryo-EM and single-channel recordings to show that acetylcholine receptor subunits transition asynchronously, leading to a sequential activation mechanism.

Heteropentameric architecture predisposes functional inequivalence of acetylcholine receptor agonist sites

This study shows that structural asymmetry in acetylcholine receptors causes functional inequivalence between chemically identical agonist sites, highlighting its role in disease and evolution.

pUdOs: concise plasmids for bacterial and mammalian cells

The paper introduces pUdOs, a set of small plasmids with flexible replication and selection markers, useful for bacterial and mammalian cells.