François Dehez

This study investigates how DrHU in Deinococcus radiodurans organizes nucleoid structure through two DNA binding modes, leading to distinct 2D and 3D arrangements under different conditions.

The paper elucidates the structural basis of the two-photon photoactivation mechanism of orange carotenoid protein using a combination of structural and biochemical methods.

InterMap accelerates interaction fingerprint detection in large molecular ensembles, achieving significant reductions in runtime and memory usage compared to existing tools.

The paper investigates how overproduction of F1F0-ATP synthase subunit b in E. coli shapes intracellular membranes through its C-terminal domain, revealing a novel mechanism for membrane structuring and adaptation to membrane stress.

The paper structures the honeybee GABAA RDL receptor to reveal three ligand binding sites and their associated conformations, highlighting allosteric modulation mechanisms and potential for new insecticides.

The paper identifies a dynamic displacement mechanism in mitochondrial protein import, showing that a flexible segment of Tom22 facilitates precursor protein release.

The paper uses cryo-EM and single-channel recordings to show that acetylcholine receptor subunits transition asynchronously, leading to a sequential activation mechanism.

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

The paper reports the cryo-EM structure of the palonosetron-bound 5-HT3 receptor and investigates binding modes of antiemetic drugs using molecular dynamics.

The paper examines the dynamics of the yeast ADP/ATP transporter AAC3 in DPC detergent and finds that observed motions are not functionally relevant to its transport mechanism.