Author

Hugues Nury

Centre National de la Recherche ScientifiqueORCID 0000-0002-3433-256XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1 Organism:human· 1

Frequent Co-Authors

Eleftherios ZarkadasiD· 3 shared François DeheziD· 3 shared Jacques Neyton· 2 shared Anna AnanchenkoiD· 1 shared Camille M. HénaultiD· 1 shared Céline Juillan‐Binard· 1 shared Christian J. G. TessieriD· 1 shared Christophe J. ChipotiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Eleftherios ZarkadasORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structures of the honeybee GABAA RDL receptor illuminate allosteric modulation

Tatiana Labouré, Mayank Prakash Pandey, Eleftherios Zarkadas, Céline Juillan‐Binard, Delphine Baud, Jacques Neyton, Thierry Cens, Matthieu Rousset, François Dehez, Pierre Charnet, Hugues Nury

The paper structures the honeybee GABAA RDL receptor to reveal three ligand binding sites and their associated conformations, highlighting allosteric modulation mechanisms and potential for new insecticides.

Neuron · Feb 6, 2026Peer-reviewedBiophysics

Asynchronous subunit transitions precede acetylcholine receptor activation

Mackenzie J. Thompson, Christian J. G. Tessier, Anna Ananchenko, Camille M. Hénault, Johnathon R. Emlaw, François Dehez, Eleftherios Zarkadas, Corrie J.B. daCosta, Hugues Nury, John E. Baenziger

The paper uses cryo-EM and single-channel recordings to show that acetylcholine receptor subunits transition asynchronously, leading to a sequential activation mechanism.

Science · Oct 2, 2025Peer-reviewedNeuroscience

The binding of palonosetron and other antiemetic drugs to the serotonin 5-HT3 receptor

Eleftherios Zarkadas, Hong Zhang, Wensheng Cai, Grégory Effantin, Jonathan Perot, Jacques Neyton, Christophe J. Chipot, Guy Schoehn, François Dehez, Hugues Nury

The paper reports the cryo-EM structure of the palonosetron-bound 5-HT3 receptor and investigates binding modes of antiemetic drugs using molecular dynamics.

Structure · Jul 28, 2020Peer-reviewedNeuroscience