Eleftherios Zarkadas

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

ULTRAPETALA1 remodels PRC2 recruitment to nucleosomes

The paper identifies a plant-specific PRC2 variant, PRC2.3, which uses ULTRAPETALA1 to target nucleosomes and deposit H3K27me3 at developmental genes.

Structures of the honeybee GABAA RDL receptor illuminate allosteric modulation

The paper structures the honeybee GABAA RDL receptor to reveal three ligand binding sites and their associated conformations, highlighting allosteric modulation mechanisms and potential for new insecticides.

Asynchronous subunit transitions precede acetylcholine receptor activation

The paper uses cryo-EM and single-channel recordings to show that acetylcholine receptor subunits transition asynchronously, leading to a sequential activation mechanism.

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

Lipid nanoemulsion incorporating DOTAP reverse micelles as clinically translatable carriers of ALDH inhibitors for lung cancer therapy

This paper develops a lipid nanoemulsion with DOTAP reverse micelles to deliver ALDH1A3 inhibitors for lung cancer treatment, showing high efficacy and structural stability.

R6G narrows BmrA conformational spectrum for a more efficient use of ATP

This study shows that Rhodamine6G binding to BmrA narrows its conformational spectrum, enhancing ATP-dependent transport efficiency.

Structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody

This study reports cryo-EM structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody, revealing conformational changes and epitope details.

The binding of palonosetron and other antiemetic drugs to the serotonin 5-HT3 receptor

The paper reports the cryo-EM structure of the palonosetron-bound 5-HT3 receptor and investigates binding modes of antiemetic drugs using molecular dynamics.