BiochemistryNature CommunicationsPeer-reviewed
Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
Shang Juan Yu, Jin-hui Ding, Jiale Wang…·Ling Liang
This study reveals the structural mechanism of cholesterol sensing by LYCHOS, showing how cholesterol binding modulates its interaction with GATOR1 to activate mTORC1.