Author

Shawn Zheng Kai Tan

University of Hong KongORCID 0000-0001-7258-9596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Lee Wei LimiD· 3 shared Brian D. AevermanniD· 2 shared Brian J StaatsiD· 2 shared Chris MungalliD· 2 shared David Osumi-SutherlandiD· 2 shared Ed S. LeiniD· 2 shared Hüseyin KıriD· 2 shared Jeremy A. MilleriD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Lee Wei LimORCID

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Author profile →

5 papers

Recent·Most cited

Brain Data Standards - A method for building data-driven cell-type ontologies

Shawn Zheng Kai Tan, Hüseyin Kır, Brian D. Aevermann, Tom Gillespie, Nomi L. Harris, Michael Hawrylycz, Nikolas L. Jorstad, Ed S. Lein, Nicolas Matentzoglu, Jeremy A. Miller, Tyler S. Mollenkopf, Chris Mungall, Patrick L. Ray, Raymond E.A. Sanchez, Brian J Staats, , David Osumi-Sutherland

The paper introduces a data-driven method to extend cell ontologies for multi-modal single-cell omics data, focusing on the Primary Motor Cortex in humans, mice, and marmosets.

Scientific Data · Jan 24, 2023Peer-reviewedNeuroscience

The BRAIN Initiative Cell Census Data Ecosystem: A User's Guide

Michael Hawrylycz, Maryann Elizabeth Martone, Patrick R. Hof, Ed S. Lein, Aviv Regev, Giorgio A. Ascoli, Jan Gunnar Bjaalie, Hong‐Wei Dong, Satrajit Ghosh, Jesse A Gillis, Ronna P. Hertzano, David R. Haynor, Yongsoo Kim, Yufeng Liu, Jeremy A. Miller, , Brian Zingg

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

bioRxiv · Oct 26, 2022 · PreprintBioinformatics

Deep Brain Stimulation of the Prelimbic Cortex Disrupts Consolidation of Fear Memories

Shawn Zheng Kai Tan, Chi Him Poon, YS Chan, Lee Wei Lim

This study shows that deep brain stimulation of the ventromedial prefrontal cortex disrupts fear memory consolidation but not acquisition or retrieval.

British Journal of Pharmacology · Apr 26, 2021Peer-reviewedNeuroscience

Dropout in Neural Networks Simulates theParadoxical Effects of Deep Brain Stimulation onMemory

Shawn Zheng Kai Tan, Richard Du, Jose Angelo Udal Perucho, Shauhrat Singh Chopra, Varut Vardhanabhuti, Lee Wei Lim

This paper shows that dropout in neural networks simulates the paradoxical effects of deep brain stimulation on memory by mimicking disruption and enhancement through training and testing phases.

Frontiers in Aging Neuroscience · Sep 14, 2020Peer-reviewedNeuroscience

Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation-induced anticipatory fear in a rat model

Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan, Andrea Tsz Ching Mok, Jose Angelo Udal Perucho, Arjan Blokland, Luca Aquili, Wei Ling Lim, Lee Wei Lim

This study shows chronic serotonergic drugs reduce dopaminergic neurons in the VTA and correlate with reduced anticipatory freezing behavior in a rat model of fear.

Brain Structure and Function · Jun 27, 2020Peer-reviewedNeuroscience