Yongsoo Kim

The paper maps DNA damage response states in aging mouse brains, revealing opposing neuronal and vascular spatial patterns linked to genome maintenance.

This study uses multi-parametric MRI to improve myelin mapping in developing mouse brains, finding that T2 imaging is the strongest predictor of myelin content.

This study shows that endogenous oxytocin alters brain network dynamics, increasing salience-related network states and decreasing sensory-dominated states in mice.

This paper introduces a scale-aware framework for spatial differential expression that improves reproducibility and identifies convergent aging programs in aged mouse brains.

This study shows that RBM8A is essential for bone development and Hedgehog signaling, with its deficiency causing skeletal defects and impaired endochondral ossification.

This paper introduces a curvilinear coordinate flatmap method to visualize hippocampal structure and development, revealing topographic variations obscured in standard coordinate systems.

The paper demonstrates the use of ANTsX for precise spatial mapping of the mouse brain using standardized coordinate systems and presents novel workflows for longitudinal trajectory analysis and automated morphological measurements.

This study maps the connectivity and function of the dorsal endopiriform nucleus in mice, revealing its role in olfaction and response to novel stimuli through Oxtr-expressing neurons.

The paper identifies a brain-wide twisting asymmetry in mice, similar to human cerebral petalia, using data from 3,500 animals across six cohorts.

The paper introduces a pipeline to profile dendritic morphology of genetically-defined single neurons in the mouse brain, revealing morphological modules and age- or HD-associated changes.

The paper develops a 3D developmental common coordinate framework (DevCCF) for mouse brains across multiple developmental stages to enable data integration and analysis of brain development.

This study identifies age-related changes in cerebrovascular structure and function in the mouse brain, including reduced vascular length and increased tortuosity in specific regions.

The paper shows that impaired capillary-venous drainage in aging mice leads to hypoperfusion, gliosis, and demyelination in deep white matter regions.

This study creates DevATLAS to map spatiotemporal circuit maturation in postnatal mouse brains and identifies molecular mechanisms and impairments in neurodevelopmental disorders.

The paper creates high-resolution 3D atlases of postnatal mouse brains and maps changes in GABAergic cells and microglia across development.

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

This study maps the whole-brain connectivity of oxytocin neurons in mice, revealing distinct roles of paraventricular and supraoptic OT neurons in circuit-specific functions.

The paper maps the spatial relationship between cerebrovasculature, pericytes, and neuronal cell types in mice to reveal how they support regional brain energy homeostasis.

The paper quantifies whole-brain XCI at single-cell resolution and finds a 60:40 paternal-to-maternal inactivation ratio that reduces disease penetrance in Fragile-X models.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.

The paper quantifies OTR cell distribution in postnatal mouse brains using fluorescent reporter mice and 3D template brains, revealing spatial and temporal patterns and sexually dimorphic nuclei.

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.

The paper merges two mouse brain atlases to create a unified anatomical labeling system with improved consistency and visualization tools.

This study identifies lineage programs in radial glial progenitors that generate striosome and matrix compartments through distinct intermediate progenitors, revealing their role in striatal circuit organization.