Danielle R. Little

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

The paper identifies 'pliancy genes' in Muller glia that enable rapid response to retinal stress, injury, and disease, showing species-specific differences in their activation between zebrafish and mammals.

The paper shows NKX2-1 uses differential chromatin binding to resolve opposing cell fates in mouse lung progenitors, with YAP/TAZ loss altering its binding sites and leading to transcriptional changes.