Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

bioRxiv · Mar 2, 2026 · PreprintNeuroscience

Latent Epigenetic Programs in Muller Glia Contribute to Stress, Injury, and Disease Response in the Retina

Jacqueline L. Norrie, Marybeth S. Lupo, Danielle R. Little, Abbas Shirinifard, Akhilesh Mishra, Qiong Zhang, Natalie Geiger, Daniel K. Putnam, Mohamed Nadhir Djekidel, Cody A. Ramirez, Beisi Xu, Jacob M. Dundee, Yu Yan Jiang, Xiang 'Anthony' Chen, Michael A. Dyer

The paper identifies 'pliancy genes' in Muller glia that enable rapid response to retinal stress, injury, and disease, showing species-specific differences in their activation between zebrafish and mammals.

Developmental Cell · Apr 1, 2025Peer-reviewedNeuroscience

The Nucleome of Developing Murine Rod Photoreceptors

Issam Aldiri, Marc B. Valentine, Beisi Xu, Daniel K. Putnam, Lyra M. Griffiths, Marybeth S. Lupo, Jacqueline L. Norrie, Jiakun Zhang, Dianna A. Johnson, John B. Easton, Ying Shao, Victoria Honnell, Sharon Frase, Shondra Miller, Valerie Stewart, , Michael A. Dyer

The paper studies the chromatin structure of rod photoreceptors in mice using Hi-C and machine learning to identify regulatory elements involved in retinal development.

bioRxiv · Jul 29, 2018 · PreprintNeuroscience