On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias
Xiaohe Tian, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, Azzurra Apriceno, Alessandro Poma, Aroa Duro‐Castaño, Manish Reddy Vuyyuru, Lena Harker-Kirschneck, Anđela Šarić, Zhongping Zhang, Pan Xiang, , Giuseppe Battaglia
This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.
Science Advances · Nov 27, 2020Peer-reviewedNeuroscience