Giuseppe Battaglia

This study models the structure of LRP1 using homology and neural network-based methods, revealing glycan-mediated dimerization and its role in stabilizing the protein's quaternary structure.

This paper develops TfR1-targeted polymersomes for colorectal cancer therapy, showing improved tumor targeting and reduced toxicity in vitro and in vivo.

This study evaluates miRNA-based therapy for medulloblastoma using a xenotransplant model, showing reduced tumor growth and invasiveness through miRNA restoration.

This study develops a multivalent scaffold targeting LRP1 at the BBB to reduce Aβ deposits and cognitive decline in AD model mice.

This study uses liquid-phase transmission electron microscopy to visualize Aβ aggregation dynamics and intermediate oligomers in solution.

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.

This study investigates how syndapin-2 mediated transcytosis affects amyloid-beta clearance across the blood-brain barrier and its implications for Alzheimer's disease and aging.

This paper demonstrates the targeting and intracellular delivery of antibiotics to mononuclear phagocytes to eradicate intracellular parasites like Mycobacterium tuberculosis.