Xiaohe Tian

A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue

This study models the structure of LRP1 using homology and neural network-based methods, revealing glycan-mediated dimerization and its role in stabilizing the protein's quaternary structure.

PARP inhibition enhances exemestane efficacy in triple-negative breast cancer

This study identifies Exemestane as a synergistic partner for Olaparib in triple-negative breast cancer, enhancing efficacy through DNA damage and apoptosis.

Multivalent Targeting of Blood-Brain Barrier LRP1 for Neurovascular Recovery Therapy for Alzheimer s Disease

This study develops a multivalent scaffold targeting LRP1 at the BBB to reduce Aβ deposits and cognitive decline in AD model mice.

On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.