Anđela Šarić

Optogenetic control of actin crosslinker length reveals a mechanical basis for cortical symmetry breaking

This study uses optogenetic control of actin crosslinker length to show how different crosslinker lengths affect cortical mechanics and drive cell polarization or delamination.

Design and self-assembly of cytomotive filaments

This paper identifies minimal monomer design principles for treadmilling filaments using physical modeling and in silico evolution, showing how conformational changes enable directional growth and fragmentation-free disassembly.

Basement membrane sets the timescale of tissue mechanical memory

The paper investigates how the basement membrane (BM) influences the mechanical memory of epithelial tissues, finding that it retains shape memory for up to four hours before permanent deformation occurs.

Supramolecular assembly of collagen mimetic peptide D-periodic fibrils and nanoassemblies

This study investigates how interhelical interactions guide the assembly of collagen mimetic peptides into D-periodic fibrils, nanotubes, and nanosheets.

Structural defects in amyloid-β fibrils drive secondary nucleation

This study shows that structural defects in amyloid-β fibrils are key sites for secondary nucleation, suggesting new strategies for drug design to inhibit amyloid disorders.

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

This study investigates how DNA segregation and cell division are coordinated in archaea, identifying regulatory checkpoints and proteins involved in ensuring accurate genome distribution.

Charge distribution of coating brush drives inter-chromosome attraction

The paper investigates how the charge distribution on Ki-67 affects RNA-mediated inter-chromosome attraction during cell division.

Non-equilibrium remodelling of collagen-IV networks in silico

This study develops coarse-grained models of collagen-IV networks and shows that non-equilibrium remodelling enables dynamic strain response not achievable through equilibrium processes.

Stability vs flexibility: reshaping archaeal membranes in silico

The paper uses a computational model to study how archaeal membrane lipids balance stability and flexibility, finding that adding bilayer lipids to bolalipid membranes achieves both.

Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking

The paper shows how caging of MCA proteins can amplify changes in membrane viscosity and protein length, leading to symmetry breaking in cellular mechanics.

On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.