Ken W.Y. Cho

This study shows Foxh1 recruits PRC2 to specific loci, silencing genes in ectoderm while activating them in endoderm during early embryogenesis.

This study identifies Foxi2 and Sox3 as master regulators of ectoderm specification in Xenopus, showing they control gene expression and epigenetic landscape through super-enhancers.

This study shows that Hdac1 maintains lineage integrity by refining the histone acetylation state during early embryogenesis.

The paper builds a genome-scale gene regulatory network for vertebrate mesendoderm development using multi-omic data integration and validates novel transcription factor interactions.

The paper shows maternal and zygotic transcription factors sequentially shape chromatin landscapes in early vertebrate embryos, leading to distinct enhancer marks in germ layers.

The paper identifies Sox17 and β-catenin interactions at enhancers that regulate endoderm gene expression and repression of mesectoderm fates during Xenopus gastrulation.

The paper uses phasor-FLIM to assess pre-implantation embryo quality by analyzing fluorescence lifetime, achieving 86% accuracy in identifying healthy embryos.