Huazhu Liang

This study shows that reducing the catalytic activity of immunotoxins while balancing receptor engagement improves their selectivity and therapeutic window.

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

The paper designs a potent inhibitor against P. sordellii lethal toxin using deep learning, showing protective effects in mice against toxic shock.