Anne Spang

This study identifies ARF-1 as a regulator of cargo sorting at FERARI-dependent endosomal recycling hubs through its cycling between active and inactive states.

SPEx enables compartment-resolved proteomics by expanding cells, microdissecting regions of interest, and analyzing them with mass spectrometry, revealing novel organelle components.

This study shows Arf1 regulates TORC1 activity in yeast by both inhibiting and promoting its function under different stress conditions.

The paper shows that non-translated mRNA levels influence the biophysical properties and composition of processing bodies (PBs) under different stress conditions.

This study identifies DRP1 and Ca2+ as essential for endocytic lysosome reformation by mediating tubule fission at ER-mitochondria-endolysosome contact sites.

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

This study shows arrestin2 binds to the β1-adrenergic receptor independently of receptor conformation or ligand type, driven by a conformational change in arrestin induced by a phosphopeptide.

The paper shows that ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are coordinated, with ESCRTs and ubiquitinated cargo regulating Rab conversion timing.

This study identifies how arrestin2 interacts with clathrin and AP2 during CCR5 endocytosis, showing that AP2 binding depends on arrestin2 activation and phosphorylation levels.

This study identifies LRBA's role in regulating the endosomal-lysosomal pathway by controlling Rab4+ endosome traffic, leading to enlarged endolysosomes in LRBA-deficient patients.

This study identifies RPL39L as an efficiency factor in cotranslational folding of alpha helical proteins by analyzing its expression, ribosome structure, and impact on translation dynamics.

The paper shows that Puf5 stabilizes transcripts to buffer mRNA levels against changes in nascent transcription mediated by H3K56A mutation, preventing synthetic lethality.

This study identifies FERARI as a conserved tethering complex involved in Rab11 recycling pathways at sorting endosomes, coordinating fusion and pinching activities.