Patrick Tschopp

The paper identifies molecular address codes in motor neurons and muscles that guide specific neuromuscular connections in tetrapod limbs through transcriptomic analysis and computational tools.

The paper uses single-cell transcriptomic data to study dietary adaptations in cichlid fish intestines, finding that anterior enterocytes drive evolutionary changes in gene expression and cell abundance.

The paper studies the transcriptional and cellular maturation of the chick spinal cord at single-cell resolution, revealing similar cell type repertoires for wings and legs and limited transcriptional changes with spatially restricted plasticity in motor neurons.

This study identifies cis-regulatory changes in the hoxdb gene cluster as the mechanism underlying parallel evolution of dorsal spine reduction in threespine stickleback fish.

The paper investigates how gene regulatory dynamics integrate lineage-specific inputs to drive skeletogenic cell fate convergence in vertebrates.

This study reprograms non-limb fibroblasts into cells with limb progenitor properties using Prdm16, Zbtb16, Lin28, and Lin41.

The paper investigates how BMP signaling dynamics self-organize to generate repeating digit patterns in tetrapods, using single-cell RNA-seq and mathematical modeling.

The paper assesses transcriptional dynamics of homologous cell types in chicken and mouse limb development using single-cell RNA-seq and identifies gene co-expression modules with varying conservation across species and developmental stages.

The paper shows that extracellular matrix gene expression can identify cell types and states better than random gene subsets and can match transcription factors in some cases.

The paper creates a single-cell RNA-seq atlas of the developing chicken limb, identifying 23 cell populations and uncovering molecular sub-populations and gene co-expression modules.

The paper investigates the role of uniform transcriptional orientation in mammalian Hox gene clusters by engineering inversions and observing their impact on gene regulation.