Christian Feregrino

This study uses deep learning and functional genomics to show that MEIS2 and TWIST1 co-regulation, along with changes in regulatory regions of PBX1, underlie bat forelimb specialization.

The paper compares bat and mouse limb development using single-cell analyses to show how a conserved gene program is repurposed in bat wing formation.

The paper investigates how gene regulatory dynamics integrate lineage-specific inputs to drive skeletogenic cell fate convergence in vertebrates.

The paper investigates how BMP signaling dynamics self-organize to generate repeating digit patterns in tetrapods, using single-cell RNA-seq and mathematical modeling.

The paper assesses transcriptional dynamics of homologous cell types in chicken and mouse limb development using single-cell RNA-seq and identifies gene co-expression modules with varying conservation across species and developmental stages.

The paper shows that extracellular matrix gene expression can identify cell types and states better than random gene subsets and can match transcription factors in some cases.

The paper creates a single-cell RNA-seq atlas of the developing chicken limb, identifying 23 cell populations and uncovering molecular sub-populations and gene co-expression modules.