Hrishikesh S. Kulkarni

This study shows lung-derived C3 initiates neutrophil recruitment in pneumonia before systemic C3, highlighting local complement's role in mucosal immunity.

This study shows that C3 modulates trained immunity in alveolar macrophages via C3aR signaling, enhancing glycolytic activity and cytokine output.

This study shows that locally produced complement factor B in the gut reduces colitis, highlighting its role in mucosal immunity.

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.

This study characterizes donor lungs used for research, finding higher prevalence of diabetes, smoking, and non-intravenous drug use compared to transplant lungs.