Manu Sharma

This study shows that tau phosphorylation patterns influence microtubule stability, with specific phosphorylations impairing tau's ability to counteract destabilization, suggesting phosphorylation may respond to, rather than precede, MT instability.

The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.

This study shows that beta-synuclein and gamma-synuclein modulate alpha-synuclein's membrane binding and synaptic function, but not its downstream roles in vesicle clustering and SNARE-complex assembly.