Alessandro Evangelisti

This paper shows that timed WNT pulses can specify distinct neural domains in human pluripotent stem cells, enabling the generation of specific neuron and progenitor types.

This study develops a method to derive and maintain specific subtypes of human midbrain dopaminergic neurons in vitro, revealing their functional and molecular characteristics and potential vulnerability in disease.

This paper presents a protocol to rapidly generate human oligodendrocytes from pluripotent stem cells using BMP and Notch signaling inhibition, achieving high purity and functional myelination.

This study develops a CRISPRa-based method to rapidly verify gene editing in human pluripotent stem cells without differentiation.

This paper develops a humanized mouse model of V122I ATTR-CM and identifies inflammatory pathways involved in its pathogenesis.

The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.