Author

Avi J. Samelson

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Martin KampmanniD· 4 shared Steven C. BoggessiD· 2 shared A. SahaiD· 1 shared Alan NapoleiD· 1 shared Alessandra RigamontiiD· 1 shared Alessandro EvangelistiiD· 1 shared Alice Maria GianiiD· 1 shared Allan YarahmadyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersNeuroscience

Martin KampmannORCID

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4 papers

Recent·Most cited

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation

Gregory A. Mohl, Gary Dixon, Emily Marzette, Justin McKetney, Avi J. Samelson, Carlota Pereda Serras, Julianne Jin, Nabeela Ariqat, Andrea Keys, Cristian Chavira, Andrew Li, Steven C. Boggess, Danielle L. Swaney, Martin Kampmann

The paper uses multi-omic analysis to study MAPT V337M neurons, finding altered axonogenesis and tau phosphorylation, with p38 MAPK pathway involvement in tau phosphorylation in V337M neurons.

npj Dementia · Apr 25, 2026Peer-reviewedNeuroscience

Prevention of Transgene Silencing During Human PluripotentStem Cell Differentiation

Takeshi Uenaka, Alan Napole, A. Saha, Duo Sun, Angelina Singavarapu, Elizabeth Calzada, Jiahui Chen, Lena Erlebach, Amanda McQuade, Daniel M. Ramos, Alessandra Rigamonti, Lisa Salazar, Avi J. Samelson, Kamilla Sedov, Natalie J. Welsh, , Marius Wernig

The paper identifies strategies to prevent transgene silencing during human pluripotent stem cell differentiation and introduces a robust vector construct.

Cell stem cell · Feb 13, 2026Peer-reviewedNeuroscience

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

Emmy Li, Camila Benitez, Steven C. Boggess, Mark Koontz, Indigo V.L. Rose, Delsy Martinez, Nina M. Dräger, Olivia M. Teter, Avi J. Samelson, Na’im Pierce, Erik M. Ullian, Martin Kampmann

The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.

Neuron · Jan 14, 2025Peer-reviewedNeuroscience

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation

C Bravo, Alice Maria Giani, Jesús Madero‐Pérez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, María del Pilar Hernández Mercedes, Tark Patel, , Li Gan

The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.

Cell · Apr 5, 2024Peer-reviewedNeuroscience