Ken‐taro Sakata

The paper uses computational models and mutagenesis to test if Rft1 is essential for M5-DLO scrambling in yeast, finding that scrambling is dispensable while M5-DLO binding is critical.

The paper identifies Com2 as a regulator of sphingolipid homeostasis in yeast, showing it is degraded via the ubiquitin-proteasome system in response to sphingolipid levels.

This study characterizes the human Rft1 protein, showing it is an ER membrane protein essential for N-glycosylation, with mutations affecting its function in congenital disorders of glycosylation.