Anant K. Menon

The paper uses computational models and mutagenesis to test if Rft1 is essential for M5-DLO scrambling in yeast, finding that scrambling is dispensable while M5-DLO binding is critical.

The paper introduces a single vesicle fluorescence microscopy platform to quantify phospholipid scrambling by VDAC1 dimers and opsin, revealing kinetic heterogeneity in scrambling rates.

The paper shows bacterial opsins function as phospholipid scramblases, independent of retinal, and highlights shared functions across domains of life.

This study characterizes the human Rft1 protein, showing it is an ER membrane protein essential for N-glycosylation, with mutations affecting its function in congenital disorders of glycosylation.