Cell BiologybioRxivPreprint
Itaconate is metabolized to 2-hydroxymethylsuccinate through a CoA-independent degradation pathway in mitochondria
Fangfang Chen, Laura Hadam, Birte Dowerg…·Thekla Cordes
The paper identifies 2-hydroxymethylsuccinate as a product of itaconate metabolism via a CoA-independent pathway and shows tissue-specific degradation routes.
DOI 10.1101/2025.09.29.679238