Author

Birte Dowerg

Helmholtz Centre for Infection Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 1

Frequent Co-Authors

Hanna F Willenbockel· 2 shared Thekla CordesiD· 2 shared Alexander Thomas WilliamsiD· 1 shared Alfredo Lucas· 1 shared André FleißneriD· 1 shared Christian M. MetalloiD· 1 shared Connor S.R. JankowskiiD· 1 shared Emeline JouliaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Hanna F Willenbockel

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Itaconate is metabolized to 2-hydroxymethylsuccinate through a CoA-independent degradation pathway in mitochondria

Fangfang Chen, Laura Hadam, Birte Dowerg, Vadim S. Korotkov, Connor S.R. Jankowski, Ulrike Beutling, Hanna F Willenbockel, Ulrike Brandt, Eva Medina, André Fleißner, Henrikus Garritsen, Michael Jarek, Raimo Franke, Thomas Weichhart, Mark Brönstrup, , Thekla Cordes

The paper identifies 2-hydroxymethylsuccinate as a product of itaconate metabolism via a CoA-independent pathway and shows tissue-specific degradation routes.

bioRxiv · Sep 29, 2025 · PreprintCell Biology

In vivo itaconate tracing reveals degradation pathway and turnover kinetics

Hanna F Willenbockel, Alexander Thomas Williams, Alfredo Lucas, Mack B. Reynolds, Emeline Joulia, Maureen L. Ruchhoeft, Birte Dowerg, Pedro Cabrales, Christian M. Metallo, Thekla Cordes

This study uses mass spectrometry and in vivo 13C tracing to show itaconate is rapidly cleared from plasma, excreted in urine, and metabolized in the liver and kidneys.

Nature Metabolism · Sep 10, 2025Peer-reviewedCell Biology