Author

Niannian Lv

Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0001-7405-4069Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Chunying CheniD· 2 shared Dongsheng LiuiD· 2 shared Jiayi LiiD· 2 shared Jinqian LiiD· 2 shared Li‐Tang YaniD· 2 shared Linqi ZhangiD· 2 shared Xinquan WangiD· 2 shared Xuanyu NaniD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Chunying ChenORCID

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2 papers

Recent·Most cited

Cell BiologyAdvanced SciencePeer-reviewedDec 7, 2025

IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by A Low-Affinity Antibody

Niannian Lv, Peng Chen, Xiaobin Dai…·Yuhe Renee Yang

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

2 citations

humanproteomics

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ImmunologyNature CommunicationsPeer-reviewedDec 4, 2024

Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization

Xuanyu Nan, Yujie Li, Rui Zhang…·Yuhe Renee Yang

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.

11 citations

cryo-EMexperimental assay

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